Hyperprogression under immunotherapy and mTOR (hypothesis) Mikhail V. Blagosklonny Abstract: Immunotherapy involving Immune Checkpoint Inhibitors can cause rapid tumor growth, particularly in patients with MDM2 amplification. MDM2 and mTOR inhibitors may mitigate this and improve therapy outcomes. Importantly, MDM2 inhibitors block mTOR in cancer cells. As MDM2 inhibitors aren’t approved for human use, mTOR inhibitors … Continue Reading

      Cancer prevention with rapamycin   Mikhail V. Blagosklonny   Introduction The mTOR (Target of Rapamycin) pathway is involved in both cancer and aging. Furthermore, common cancers are age-related diseases, and their incidence increases exponentially with age. In theory, rapamycin (sirolimus) and other rapalogs (temsirolimus, everolimus) may delay cancer by targeting directly pre-cancerous … Continue Reading